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FRCPath Haem Part 1 MCQ-Oncology 328

A 38yr-old patient with Ph-negative B-ALL has persistent MRD of 0.05% after 3 treatment blocks. He is otherwise clinically stable. Most appropriate next step?

  • Continue maintenance therapy

  • Observe and repeat MRD in 6 months

  • Change therapy using blinatumomab and plan for SCT

  • Add rituximab regardless of CD20 status

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