FRCPath Haem Part 1 MCQ-Oncology 345

A 52yr-old pt with relapsed DLBCL is planned for further doxorubicin-containing chemotherapy. EF 45%. Which of following is appropriate to reduce cardiac risks?

• Substitute doxorubicin with cisplatin and give amifostine
• Administer mesna concurrently with doxorubicin
• Add dexrazoxane prior to further anthracycline dosing
• Use high-dose leucovorin rescue after chemotherapy

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