top of page
Search

FRCPath Haem part 1 MCQ-Oncology 381

A 50-year-old man with HCL received Pentostatin first-line, achieved CR, but relapsed after 18 months. Next best treatment?

  • Rituximab monotherapy

  • Moxetumumab Trial

  • Re-treat with Pentostatin

  • Re-treat with Pentostatin and Add Rituximab


 
 
 

1 Comment

adwaan567
a day ago

Correct Answer: Cladribine


This is classic hairy cell leukaemia (HCL) management.

Key points:

  • He received Pentostatin first-line → achieved CR

  • Relapse at 18 months = early relapse (<2 years)


What that means

  • CR lasting >2 years:

    • Re-treat with same agent & can add Rituximab to either

  • CR lasting <2 years:

    • Whichever purine analogue wasn’t use first line


👉 Next best treatment

Cladribine ( but cladribine + rituximab is most commonly cited)

Like
bottom of page