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FRCPath Haem Part 1 MCQ-Oncology 402

A lymph node biopsy from pt shows population of atypical lymphoid cells. Flow: CD3+4+7-25+19-56-. Expected molecular alteration in this condition?

  • BRAF V600E mutation

  • TEL-AML1

  • MYD88 L265P mutation

  • t(11;14)


 
 
 

1 Comment

adwaanhemay
5 hours ago

Correct Answer: CTLA4–CD28 fusion


The immunophenotype given:

  • CD3+

  • CD4+

  • CD7−

  • CD25+

  • CD19−, CD56−

This is classic for Adult T-cell leukemia/lymphoma (ATLL).

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