FRCPath Haem Part 1 MCQ-Transplant 405

A 58yr-old pt with relapsed DLBCL is planned for autologous SCT. Mobilization with GCSF-poor CD34+cells yield. Plerixafor added. Its mechanism of action?

• Stimulates proliferation of CD34+ cells in the bone marrow
• Upregulates SDF-1 in the bone marrow to attract stem cells.
• Increases G-CSF receptor expression on progenitor cells.
• Antagonizes CXCR4 on hematopoietic stem cells

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