FRCPath Haem Part 1 MCQs-Gen Haem 495

A 18-year-old man is reviewed in the haematology clinic. He has a long-standing history of hepatosplenomegaly, thrombocytopenia and skeletal complications. He has distal expansion of of the femur.

Over the last three months, he has developed worsening fatigue and persistent lower back pain. Investigations reveal a normocytic anaemia, significant thrombocytopenia and raised serum total protein. US abdomen revealed significant hepatomegaly, splenomegaly of 20cm.

Which of the following haematological malignancies is particularly associated with this disease?

A. Acute myeloid leukaemia (AML)

B. Chronic lymphocytic leukaemia (CLL)

C. Multiple myeloma

D. Chronic myeloid leukaemia (CML)

E. Hodgkin lymphoma