FRCPath Haem Part 1 MCQs-Haemostasis 509

A 24-year-old woman is referred to the haematology clinic with a history of recurrent epistaxis, easy bruising and heavy menstrual bleeding. Her platelet count is mildly reduced at 115 × 10⁹/L. Coagulation screening is otherwise normal.

Light transmission aggregometry (LTA) is performed using platelet-rich plasma. The results demonstrate:

• Normal aggregation responses to ADP, collagen, adrenaline and arachidonic acid.

• Enhanced platelet aggregation in response to low-dose ristocetin.

• Preserved response to high-dose ristocetin.

Which of the following is the most likely diagnosis?

A. Glanzmann thrombasthenia

B. Bernard–Soulier syndrome

C. Type 2B von Willebrand disease

D. Aspirin-induced platelet dysfunction

E. Quebec platelet disorder