FRCPath Haem Part 1 MCQs-Transfusion 506 🩸🩸

A 29-year-old woman of childbearing potential, known to be RhD-negative, is admitted following a major road traffic accident with massive haemorrhage. During resuscitation, she inadvertently receives 10 units of RhD-positive red cells because of an inadequate supply of RhD-negative blood.

Following stabilisation, the transfusion medicine team recommends a red cell exchange transfusion to remove the circulating RhD-positive red cells and reduce the risk of RhD alloimmunisation. A 1–2 red cell volume exchange is performed.

which of the following is the most appropriate method and timing for assessing the residual circulating RhD-positive red cell volume following exchange transfusion?

Options

A. Perform a Kleihauer–Betke test immediately after exchange transfusion

B. Perform flow cytometry immediately after completion of the 1–2 volume red cell exchange

C. Perform flow cytometry 48 hours after completion of the red cell exchange

D. Perform flow cytometry 72 hours after completion of the red cell exchange

E. Perform a Kleihauer–Betke test 48 hours after exchange transfusion

F. Perform routine serological RhD grouping 24 hours after exchange transfusion