FRCPath Haem Part 1MCQ-Gen Haem 183

A 3yr-old pt present with chronic haemolytic anemia. Blood film show marked poikilocytosis with microspherocyte and fragmented cell. Expected molecular finding?

• Spectrin deficiency due to α-spectrin mutation
• Band 3 deficiency
• β-spectrin mutation causing abnormal ankyrin binding
• Pyruvate kinase deficiency

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