FRCPath Haem Part 1 MCQ-Gen Haem 133

62yr old Pt with DLBCL is scheduled to start R-CHOP chemotherapy. Allergic to Allopurinol and considered as Intermediate TLS risk. Best step to prevent TLS?

• No prophylaxis required in Intermediate risk TLS
• Rasburicase 0.2 mg/kg after uric acid rises
• Febuxostat 120 mg once daily before chemotherapy
• Low dose Allopurinol 150mg OD

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