FRCPath Haem Part 1 MCQ-Gen Haem 395

A 19yr-old man presents with recurrent painful crises since childhood. Hb 78g/l and MCV 66fl.HPLC shows: HbS: 88%, HbF: 8%, HbA₂: 4.8% and HbA: 0%. Diagnosis?

• Homozygous sickle cell disease
• Sickle cell trait
• HbSC disease
• Sickle β⁺ thalassemia

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