FRCPath Haem Part 1 MCQ-Haemostasis 122

25yr-old pt is investigated for bruising. She receives DDAVP. VWF Ag rises by 1hr but fall rapidly at 6hours . Which of these would strongly support diagnosis?

• Loss of high-molecular-weight multimers
• Abnormal ristocetin-induced platelet aggregation
• Rapid decline of VWF levels following DDAVP
• Abnormal FVIII: VWB Ag ratio

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