FRCPath Haem Part 1 MCQ-Haemostasis 59

A 12yr-old boy present with recurrent soft tissue haematoma and history of poor wound healing. Uncle died of ICH. PT, APTT, Fibrinogen, Thrombin normal. Reason?

• Inability to convert fibrinogen to fibrin monomers
• Impaired cross-linking of fibrin polymer by transglutaminase
• Excess plasmin activity due to low α2-antiplasmin
• Impaired platelet adhesion to collagen

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