FRCPath Haem Part 1 MCQ-Oncology 125

A 52yr-old man with aggressive systemic Mastocytosis is being considered for Avapritinib. He has Plts 45, Hb 85  and normal LFTs. Appropriate next step?

• Start avapritinib at standard dose
• Start avapritinib at reduced dose with close monitoring
• Correct thrombocytopenia before starting avapritinib
• Switch to midostaurin immediately

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