FRCPath Haem Part 1 MCQ-Oncology 206

A 42-year-old patient with Acute Promyelocytic Leukaemia on ATRA develops dyspnoea, hypotension, and pulmonary infiltrates. What is the first-line treatment?

• Stop ATRA and start high-dose cytarabine
• Continue ATRA and prescribe IV Fluids with antibiotics
• Stop ATRA and increase/prescribe dexamethasone dose
• Switch to arsenic trioxide and withhold ATRA

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