FRCPath Haem Part 1 MCQs-Mutation 484

A 68-year-old man is investigated for persistent neutrophilic leukocytosis. His WCC is 42 × 10⁹/L, with predominantly mature neutrophils and minimal left shift. There is no significant dysgranulopoiesis, blasts account for <1%, and he has moderate splenomegaly. BCR::ABL1 is not detected.

Which of the following mutations is most strongly associated with this condition?

A. SETBP1

B. ANKRD26

C. STAT5B

D. CSF3R

E. LMAN1

F. NBEAL2