FRCPath Haem Part 1 MCQ-Transfusion 31
- amirhayat2527
- Aug 29, 2025
- 0 min read
Updated: Aug 30, 2025
A 45-year-old patient who is Group O RhD negative receives a stem cell graft from a group A RhD+ donor. Which complication can happen in the future?
Passenger Lymphocyte syndrome
Haemolysis of the recipient red cell
Pure red cell aplasia
Secondary malignancy
Pure red cell aplasia is a diagnosis not clinical symptom of some diagnosis. Pure red cell aplasia is diagnosed when there is a bonemarrow failure. in this there is ABO mismatch and Rh mismatch,, due to antibodies there will be hemolysis (lysis of peripheral red cells) not a suppression of red cell production from marrow
Correct Answer: Pure red cell aplasia. This is Major ABO mismatch so donor cells will be acutely haemolysed not recipient as recipient is O and has more antibodies
i think 2 options are correct, one for major ABO mismatch and one for RH mismatch. please clear me.