FRCPath Haem Part 1 MCQs-Oncology 470

A 46-year-old man is referred to the haematology clinic with a 4-month history of progressive fatigue, drenching night sweats, weight loss, and generalized pruritus. He has recently developed cervical and axillary lymphadenopathy. Examination demonstrates generalized lymphadenopathy, moderate hepatosplenomegaly, and a widespread erythematous rash.

Full blood count reveals:

• Hb: 102 g/L

• WBC: 58.4 × 10⁹/L

• Eosinophils: 18.6 × 10⁹/L

• Platelets: 118 × 10⁹/L

Peripheral blood film shows marked eosinophilia with occasional dysplastic eosinophils and circulating atypical lymphoid cells.

Bone marrow examination demonstrates a hypercellular marrow with marked eosinophilic proliferation and an abnormal population of immature T lymphoblasts expressing CD2, CD5, CD7, cytoplasmic CD3, TdT, and lacking surface CD3.

The multidisciplinary team suspects an aggressive myeloid/lymphoid neoplasm with eosinophiliahaving FGFR1 muatation.

Which of the following chromosomal translocations is most characteristic of this condition?

A. t(6:9)

B. t(12:21)

C. t(8;13)

D. T(8:16)

E. t(8:21)