FRCPath Haem Part 1MCQ- Transfusion 103

A pt with multiple myeloma receiving daratumumab requires RBC transfusion. Pre-transfusion testing show pan-reactive antibody screen. most appropriate next step

• Administer ABO/RhD-compatible red blood cells only
• Perform an eluate on the patient’s red cells
• Treat donor red cells with dithiothreitol and perform screen
• Switch the patient to an alternative anti-CD38 therapy

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