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FRCPath Haem Part 1 MCQ-Gen Haem 201b

A 68yr pt had a bone marrow biopsy due to low counts, splenomegaly and backpain. A toluidine blue stain is used on biopsy, which is useful for diagnosis of?

  • Hairy cell leukaemia

  • Hodgkin lymphoma

  • Mastocytosis

  • Chronic lymphocytic leukaemia


 
 
 

1 Comment

adwaan567
Oct 27

Correct Answer: Mastocytosis


Key points:

  • Toluidine blue stains mast cell granules purple-red.

  • Other helpful stains: Giemsa, tryptase, and CD117 (c-Kit) immunostaining.

  • Systemic Mastocytosis often presents with marrow infiltration, cytopenias, splenomegaly, and bone pain/osteosclerosis.

  • The characteristic trephine feature is per-trabecular marrow fibrosis


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