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FRCPath Haem Part 1 MCQ-Oncology 176

70yr-old pt with relapsed CLL starts ibrutinib. Initial Counts. Hb 110, WCC 255, L 24 and Plt 140. After 2 wks of treatment: WCC 321 and L 310. Next best step?

  • Stop ibrutinib — disease progression

  • Add corticosteroids to reduce lymphocytosis

  • Continue ibrutinib — expected transient lymphocytosis

  • Add venetoclax due to ibrutinib failure

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