FRCPath Haem Part 1 MCQ-Oncology 245

A 16yr-old boy with ALL on induction therapy including asparaginase develops catheter-related DVT. Labs: fibrinogen 0.9 g/L, antithrombin 28%. Likely mechanism?

• Increased hepatic production of coagulation proteins
• Direct inhibition of thrombin by asparaginase
• Asparaginase-induced reduction of hepatic protein synthesis
• Immune-mediated fibrinogen destruction

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